Phenomena and Processes

Clonal Hematopoiesis

Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).

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Synonyms

13 entry terms
  • Hematopoiesis, Clonal
  • ARCH Age-related Clonal Hematopoiesis
  • Age-related Clonal Hematopoiesis
  • CCUS Clonal Cytopenia of Undetermined Significance
  • CHIP Clonal Hematopoiesis of Indeterminate Potential
  • Clonal Cytopenia of Undetermined Significance
  • Clonal Hematopoiesis of Indeterminate Potential
  • ICUS Idiopathic Cytopenias of Undetermined Significance
  • Idiopathic Cytopenias of Undetermined Significance
  • ARCH Age related Clonal Hematopoiesis
  • Age related Clonal Hematopoiesis
  • Clonal Hematopoiesis, Age-related
  • Hematopoiesis, Age-related Clonal

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Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

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History Note

2021

MeSH Record

Previous Indexing

  • Hematopoiesis (1989-2020)

MeSH Hierarchy

Tree Numbers

  1. G04.152w.825w.207w
  2. G04.375w.500w
  3. G05.158w.500w
  4. G09.188.343w.207w

AMA Style

References

  1. National Library of Medicine. Clonal Hematopoiesis. Medical Subject Headings (MeSH). 2026. Unique ID D000082182. http://id.nlm.nih.gov/mesh/2026/D000082182
  2. Clonal Hematopoiesis. In: Wikipedia. https://en.wikipedia.org/wiki/Clonal_hematopoiesis
  3. Clonal Hematopoiesis. In: Wikidata. https://www.wikidata.org/wiki/Q30314746