Chemicals and Drugs

Clomipramine

A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.

Chemical Identity

Chemical Information

Molecular Formula
C19H23ClN2
Molecular Weight
314.9 g/mol
CAS Registry No.
303-49-1
IUPAC Name
3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
InChIKey
GDLIGKIOYRNHDA-UHFFFAOYSA-N
SMILES
CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
MeSH Unique ID
D002997
Source
PubChem CID 2801

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Chlomipramine
  • Chlorimipramine
  • Anafranil
  • Clomipramine Hydrochloride
  • Clomipramine Maleate (1:1)
  • Clomipramine Monohydrochloride
  • Hydiphen
  • Hydrochloride, Clomipramine
  • Monohydrochloride, Clomipramine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

80(75); was CHLORIMIPRAMINE see under DIBENZAZEPINES 1968-79

MeSH Record

Previous Indexing

  • Dibenzazepines (1968-1974)

MeSH Hierarchy

Tree Number

  1. D03w.633.300.240.194w

MeSH Record

NLM Classification

QV 77.5

AMA Style

References

  1. National Library of Medicine. Clomipramine. Medical Subject Headings (MeSH). 2026. Unique ID D002997. http://id.nlm.nih.gov/mesh/2026/D002997
  2. Clomipramine. In: Wikipedia. https://en.wikipedia.org/wiki/Clomipramine
  3. Clomipramine. In: Wikidata. https://www.wikidata.org/wiki/Q58713
  4. Clomipramine. In: PubChem Compound. CID 2801. https://pubchem.ncbi.nlm.nih.gov/compound/2801