Chemicals and Drugs

Clofazimine

A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)

Chemical Identity

Chemical Information

Molecular Formula
C27H22Cl2N4
Molecular Weight
473.4 g/mol
CAS Registry No.
2030-63-9
IUPAC Name
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
InChIKey
WDQPAMHFFCXSNU-UHFFFAOYSA-N
SMILES
CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl
MeSH Unique ID
D002991
Source
PubChem CID 2794

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-((1-methylethyl)imino)-2-phenazinamine
  • B-663
  • G-30,320
  • Lamprene
  • B 663
  • B663
  • G 30,320
  • G30,320

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

74

MeSH Hierarchy

Tree Number

  1. D03w.633.300.704w.353w

AMA Style

References

  1. National Library of Medicine. Clofazimine. Medical Subject Headings (MeSH). 2026. Unique ID D002991. http://id.nlm.nih.gov/mesh/2026/D002991
  2. Clofazimine. In: Wikipedia. https://en.wikipedia.org/wiki/Clofazimine
  3. Clofazimine. In: Wikidata. https://www.wikidata.org/wiki/Q418611
  4. Clofazimine. In: PubChem Compound. CID 2794. https://pubchem.ncbi.nlm.nih.gov/compound/2794