Chemicals and Drugs

Clofarabine

An adenine arabinonucleoside derivative that acts as an antineoplastic antimetabolite. It is used in the treatment of ACUTE LYMPHOID LEUKEMIA in pediatric patients who have relapsed.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An adenine arabinonucleoside derivative that acts as an antineoplastic antimetabolite. It is used in the treatment of ACUTE LYMPHOID LEUKEMIA in pediatric patients who have relapsed.

Chemical Identity

Chemical Information

Molecular Formula
C10H11ClFN5O3
Molecular Weight
303.68 g/mol
CAS Registry No.
123318-82-1
IUPAC Name
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
InChIKey
WDDPHFBMKLOVOX-AYQXTPAHSA-N
SMILES
C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)Cl)N
MeSH Unique ID
D000077866
Source
PubChem CID 119182

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • 2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine
  • 2-Chloro-2'-fluoroarabino-2'-deoxyadenosine
  • 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arbinofuranosyl)adenine
  • 2-Chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
  • 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-
  • Cl-F-ara-A
  • 2 Chloro 2' arabino fluoro 2' deoxyadenosine
  • 2 Chloro 2' fluoroarabino 2' deoxyadenosine
  • Clofarex
  • Clolar
  • Evoltra

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1991)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.759.646.138.309w
  2. D13.570w.065.195w
  3. D13.695w.667.138.309w
  4. D13.695w.827w.068.309w

AMA Style

References

  1. National Library of Medicine. Clofarabine. Medical Subject Headings (MeSH). 2026. Unique ID D000077866. http://id.nlm.nih.gov/mesh/2026/D000077866
  2. Clofarabine. In: Wikipedia. https://en.wikipedia.org/wiki/Clofarabine
  3. Clofarabine. In: Wikidata. https://www.wikidata.org/wiki/Q5134875
  4. Clofarabine. In: PubChem Compound. CID 119182. https://pubchem.ncbi.nlm.nih.gov/compound/119182