Chemicals and Drugs

Clioquinol

A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.

Chemical Identity

Chemical Information

Molecular Formula
C9H5ClINO
Molecular Weight
305.50 g/mol
CAS Registry No.
130-26-7
IUPAC Name
5-chloro-7-iodoquinolin-8-ol
InChIKey
QCDFBFJGMNKBDO-UHFFFAOYSA-N
SMILES
C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1
MeSH Unique ID
D007464
Source
PubChem CID 2788

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

14 entry terms
  • 5-Chloro-7-iodo-8-quinolinol
  • Chloroiodoquine
  • Iodochlorhydroxyquin
  • Iodochloroxyquinoline
  • 5 Chloro 7 iodo 8 quinolinol
  • Chinoform
  • Entero-Septol
  • Entero-Vioform
  • Enteroquinol
  • Vioform
  • Entero Septol
  • Entero Vioform
  • EnteroSeptol
  • EnteroVioform

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was IODOCHLORHYDROXYQUIN 1963-92 (see under HYDROXYQUINOLINES 1983-90); CLIOQUINOL was see IODOCHLORHYDROXYQUIN 1976-92

MeSH Hierarchy

Tree Number

  1. D03w.633.100.810.350.625w.400w

AMA Style

References

  1. National Library of Medicine. Clioquinol. Medical Subject Headings (MeSH). 2026. Unique ID D007464. http://id.nlm.nih.gov/mesh/2026/D007464
  2. Clioquinol. In: Wikipedia. https://en.wikipedia.org/wiki/Clioquinol
  3. Clioquinol. In: Wikidata. https://www.wikidata.org/wiki/Q5134338
  4. Clioquinol. In: PubChem Compound. CID 2788. https://pubchem.ncbi.nlm.nih.gov/compound/2788