Chemicals and Drugs

Cleavage And Polyadenylation Specificity Factor

An RNA-binding protein that recognizes the AAUAAA RNA SEQUENCE at the 3' end of MRNA. It contains four subunits of 30, 73, 100 and 160 kDa molecular size and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An RNA-binding protein that recognizes the AAUAAA RNA SEQUENCE at the 3' end of MRNA. It contains four subunits of 30, 73, 100 and 160 kDa molecular size and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

24 entry terms
  • CPSF Protein
  • Cleavage-Polyadenylation Specificity Factor
  • Cleavage Polyadenylation Specificity Factor
  • CPSF 30K
  • CPSF-100-kDa Subunit
  • CPSF-160-kDa Subunit
  • CPSF-30-kDa Subunit
  • CPSF-73-kDa Subunit
  • Cleavage And Polyadenylation Specificity Factor, 100-kDa Subunit
  • Cleavage And Polyadenylation Specificity Factor, 160-kDa Subunit
  • Cleavage And Polyadenylation Specificity Factor, 30-kDa Subunit
  • Cleavage And Polyadenylation Specificity Factor, 73-kDa Subunit
  • CPSF 100 kDa Subunit
  • CPSF 160 kDa Subunit
  • CPSF 30 kDa Subunit
  • CPSF 73 kDa Subunit
  • Cleavage And Polyadenylation Specificity Factor, 100 kDa Subunit
  • Cleavage And Polyadenylation Specificity Factor, 160 kDa Subunit
  • Cleavage And Polyadenylation Specificity Factor, 30 kDa Subunit
  • Cleavage And Polyadenylation Specificity Factor, 73 kDa Subunit
  • Subunit, CPSF-100-kDa
  • Subunit, CPSF-160-kDa
  • Subunit, CPSF-30-kDa
  • Subunit, CPSF-73-kDa

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; for CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR use MRNA CLEAVAGE AND POLYADENYLATION FACTORS (NM) 1992-2002

MeSH Record

Previous Indexing

  • RNA-Binding Proteins (1992-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.725w.124.240w
  2. D12.776w.664w.962w.444.240w

AMA Style

References

  1. National Library of Medicine. Cleavage And Polyadenylation Specificity Factor. Medical Subject Headings (MeSH). 2026. Unique ID D039223. http://id.nlm.nih.gov/mesh/2026/D039223
  2. Cleavage And Polyadenylation Specificity Factor. In: Wikipedia. https://en.wikipedia.org/wiki/Cleavage_and_polyadenylation_specificity_factor
  3. Cleavage And Polyadenylation Specificity Factor. In: Wikidata. https://www.wikidata.org/wiki/Q21100335