Structured Summary
Abstract
Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
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Classification
Broader headings
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Synonyms
3 entry terms
- Classical Complement Activation Pathway
- Complement Activation Pathway, Classical
- Complement Pathway, Classical
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Aspects Covered
6 allowable subheadings
Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.
MeSH Record
History Note
91(79); was see under COMPLEMENT ACTIVATION 1979-90
MeSH Record
Previous Indexing
- Complement (1966-1978)
- Complement Fixation Tests (1966-1978)
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MeSH Record
NLM Classification
QW 680
AMA Style
References
- National Library of Medicine. Classical Complement Pathway. Medical Subject Headings (MeSH). 2026. Unique ID D003171. http://id.nlm.nih.gov/mesh/2026/D003171
- Classical Complement Pathway. In: Wikipedia. https://en.wikipedia.org/wiki/Classical_complement_pathway
- Classical Complement Pathway. In: Wikidata. https://www.wikidata.org/wiki/Q5128320