Chemicals and Drugs

Cilastatin

A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

Chemical Identity

Chemical Information

Molecular Formula
C16H26N2O5S
Molecular Weight
358.5 g/mol
CAS Registry No.
82009-34-5
IUPAC Name
(Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid
InChIKey
DHSUYTOATWAVLW-WFVMDLQDSA-N
SMILES
CC1(C[C@@H]1C(=O)N/C(=C\CCCCSC[C@@H](C(=O)O)N)/C(=O)O)C
MeSH Unique ID
D015377
Source
PubChem CID 6435415

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • Cilastatin Monosodium Salt
  • Cilastatin Sodium
  • MK 0791
  • MK-791
  • MK0791
  • MK 791
  • MK791
  • Monosodium Salt, Cilastatin
  • Salt, Cilastatin Monosodium
  • Sodium, Cilastatin

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • Cyclopropanes (1983-1988)
  • Dipeptidases/antagonists & inhibitors (1983-1988)
  • Protease Inhibitors (1983-1988)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.392.368w.533w.200w
  2. D10w.251w.355w.325w.200w

AMA Style

References

  1. National Library of Medicine. Cilastatin. Medical Subject Headings (MeSH). 2026. Unique ID D015377. http://id.nlm.nih.gov/mesh/2026/D015377
  2. Cilastatin. In: Wikipedia. https://en.wikipedia.org/wiki/Cilastatin
  3. Cilastatin. In: Wikidata. https://www.wikidata.org/wiki/Q418201
  4. Cilastatin. In: PubChem Compound. CID 6435415. https://pubchem.ncbi.nlm.nih.gov/compound/6435415