Diseases

Chronic Fatigue Syndrome

A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

22 entry terms
  • Chronic Fatigue Disorder
  • Chronic Fatigue and Immune Dysfunction Syndrome
  • Chronic Fatigue-Fibromyalgia Syndrome
  • Encephalomyelitis, Myalgic
  • Fatigue Syndrome, Chronic
  • Infectious Mononucleosis-Like Syndrome, Chronic
  • Myalgic Encephalomyelitis
  • Postviral Fatigue Syndrome
  • Royal Free Disease
  • Systemic Exertion Intolerance Disease
  • Chronic Fatigue Disorders
  • Chronic Fatigue Fibromyalgia Syndrome
  • Chronic Fatigue Syndromes
  • Chronic Fatigue-Fibromyalgia Syndromes
  • Fatigue Disorder, Chronic
  • Fatigue Syndrome, Postviral
  • Fatigue Syndromes, Chronic
  • Fatigue-Fibromyalgia Syndrome, Chronic
  • Fatigue-Fibromyalgia Syndromes, Chronic
  • Infectious Mononucleosis Like Syndrome, Chronic
  • Postviral Fatigue Syndromes
  • Syndrome, Postviral Fatigue

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

a clinical entity: do not confuse with "chronic fatigue" (= FATIGUE + CHRONIC DISEASE (NIM))

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Encephalomyelitis (1966-1989)
  • Fatigue (1977-1989)
  • Muscular Diseases (1966-1989)
  • Virus Diseases (1986-1989)

MeSH Hierarchy

Tree Numbers

  1. C05w.651w.310w
  2. C10w.586.500w.600w
  3. C10w.668w.364w
  4. C23.550.291.500w.392w

AMA Style

References

  1. National Library of Medicine. Chronic Fatigue Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D015673. http://id.nlm.nih.gov/mesh/2026/D015673
  2. Chronic Fatigue Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome
  3. Chronic Fatigue Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q209733