Structured Summary
Abstract
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
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Synonyms
1 entry terms
- Immunoprecipitation, Chromatin
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14 allowable subheadings
Indexed with the subheadings adverse effects, classification, economics, ethics, history, instrumentation, methods, mortality, nursing, psychology, standards, statistics & numerical data, trends, veterinary.
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History Note
2005
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Previous Indexing
- Precipitin Tests (2000-2004)
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References
- National Library of Medicine. Chromatin Immunoprecipitation. Medical Subject Headings (MeSH). 2026. Unique ID D047369. http://id.nlm.nih.gov/mesh/2026/D047369
- Chromatin Immunoprecipitation. In: Wikipedia. https://en.wikipedia.org/wiki/Chromatin_immunoprecipitation
- Chromatin Immunoprecipitation. In: Wikidata. https://www.wikidata.org/wiki/Q901026