Chemicals and Drugs

Chondroitin Lyases

Enzymes which catalyze the elimination of delta-4,5-D-glucuronate residues from polysaccharides containing 1,4-beta-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages thereby bringing about depolymerization. EC 4.2.2.4 acts on chondroitin sulfate A and C as well as on dermatan sulfate and slowly on hyaluronate. EC 4.2.2.5 acts on chondroitin sulfate A and C.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Enzymes which catalyze the elimination of delta-4,5-D-glucuronate residues from polysaccharides containing 1,4-beta-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages thereby bringing about depolymerization. EC 4.2.2.4 acts on chondroitin sulfate A and C as well as on dermatan sulfate and slowly on hyaluronate. EC 4.2.2.5 acts on chondroitin sulfate A and C.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

12 entry terms
  • Lyases, Chondroitin
  • Chondroitin AC Lyase
  • Chondroitin B Lyase
  • Chondroitin Eliminase
  • Chondroitin Sulfate Lyase
  • Chondroitinase-AC II
  • Chondroitinase AC II
  • Eliminase, Chondroitin
  • Lyase, Chondroitin AC
  • Lyase, Chondroitin B
  • Lyase, Chondroitin Sulfate
  • Sulfate Lyase, Chondroitin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not confuse with CHONDROITIN ABC LYASE

MeSH Record

History Note

91(76); was see under CHONDROITINASES 1976-90

MeSH Record

Previous Indexing

  • Chondroitin (1970-1975)
  • Lyases (1970-1974)
  • Polysaccharide-Lyases (1975)

MeSH Hierarchy

Tree Number

  1. D08.811w.520w.241.700.350.500

AMA Style

References

  1. National Library of Medicine. Chondroitin Lyases. Medical Subject Headings (MeSH). 2026. Unique ID D002808. http://id.nlm.nih.gov/mesh/2026/D002808
  2. Chondroitin Lyases. In: Wikidata. https://www.wikidata.org/wiki/Q76529526