Chemicals and Drugs

Cholecystokinin Receptors

Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood.

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Synonyms

24 entry terms
  • CCK Receptor
  • CCK Receptors
  • Cholecystokinin Receptor
  • Pancreozymin Receptors
  • Receptors, CCK
  • Receptors, Cholecystokinin
  • Receptors, Pancreozymin
  • Receptor, CCK
  • Receptor, Cholecystokinin
  • CCK-4 Receptors
  • CCK-8 Receptors
  • Caerulein Receptors
  • Cholecystokinin Octapeptide Receptors
  • Receptors, CCK-4
  • Receptors, CCK-8
  • Receptors, Caerulein
  • Receptors, Cholecystokinin Octapeptide
  • Receptors, Sincalide
  • Sincalide Receptors
  • CCK 4 Receptors
  • CCK 8 Receptors
  • Octapeptide Receptors, Cholecystokinin
  • Receptors, CCK 4
  • Receptors, CCK 8

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

87

MeSH Record

Previous Indexing

  • Cholecystokinin (1966-1986)
  • Receptors, Endogenous Substances (1973-1986)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.543w.750w.695w.170w
  2. D12.776w.543w.750w.720w.600w.270w
  3. D12.776w.543w.750w.750w.360.200w
  4. D12.776w.543w.750w.750w.555w.270w

MeSH Record

NLM Classification

WK 170

AMA Style

References

  1. National Library of Medicine. Cholecystokinin Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D011949. http://id.nlm.nih.gov/mesh/2026/D011949
  2. Cholecystokinin Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/Cholecystokinin_receptor
  3. Cholecystokinin Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q24788694