Chemicals and Drugs

Chlorpheniramine

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.

Chemical Identity

Chemical Information

Molecular Formula
C16H19ClN2
Molecular Weight
274.79 g/mol
CAS Registry No.
132-22-9
IUPAC Name
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
InChIKey
SOYKEARSMXGVTM-UHFFFAOYSA-N
SMILES
CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
MeSH Unique ID
D002744
Source
PubChem CID 2725

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

20 entry terms
  • Chlorphenamine
  • Chlorprophenpyridamine
  • Aller-Chlor
  • Antihistaminico Llorens
  • Chlo-Amine
  • Chlor-100
  • Chlor-Trimeton
  • Chlor-Tripolon
  • Chlorpheniramine Maleate
  • Chlorpheniramine Tannate
  • Chlorpro
  • Chlorspan 12
  • Chlortab-4
  • Cloro-Trimeton
  • Efidac 24
  • Kloromin
  • Piriton
  • Teldrin
  • Maleate, Chlorpheniramine
  • Tannate, Chlorpheniramine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

a histamine H1 antag & antipruritic

MeSH Record

History Note

65(63)

MeSH Hierarchy

Tree Number

  1. D03w.383.725w.620w.150w

MeSH Record

NLM Classification

QV 157

AMA Style

References

  1. National Library of Medicine. Chlorpheniramine. Medical Subject Headings (MeSH). 2026. Unique ID D002744. http://id.nlm.nih.gov/mesh/2026/D002744
  2. Chlorpheniramine. In: Wikipedia. https://en.wikipedia.org/wiki/Chlorphenamine
  3. Chlorpheniramine. In: Wikidata. https://www.wikidata.org/wiki/Q420133
  4. Chlorpheniramine. In: PubChem Compound. CID 2725. https://pubchem.ncbi.nlm.nih.gov/compound/2725