Chemicals and Drugs

Checkpoint Kinase 2

Enzyme activated in response to DNA DAMAGE involved in cell cycle arrest. The gene is located on the long (q) arm of chromosome 22 at position 12.1. In humans it is encoded by the CHEK2 gene.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Enzyme activated in response to DNA DAMAGE involved in cell cycle arrest. The gene is located on the long (q) arm of chromosome 22 at position 12.1. In humans it is encoded by the CHEK2 gene.

MeSH Record

Classification

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MeSH Record

Synonyms

24 entry terms
  • CDS1 Kinase
  • CHEK2 Kinase
  • Checkpoint-Like Protein CHK2
  • Chk2 Protein Kinase
  • LFS2 Protein Kinase
  • PP1425 Protein Kinase
  • Serine Threonine Protein Kinase Chk2
  • Serine-Threonine-Protein Kinase CHK2
  • hCHK2 Kinase
  • CHK2, Checkpoint-Like Protein
  • CHK2, Serine-Threonine-Protein Kinase
  • Checkpoint Like Protein CHK2
  • Kinase 2, Checkpoint
  • Kinase CHK2, Serine-Threonine-Protein
  • Kinase, CDS1
  • Kinase, CHEK2
  • Kinase, Chk2 Protein
  • Kinase, LFS2 Protein
  • Kinase, PP1425 Protein
  • Kinase, hCHK2
  • Protein CHK2, Checkpoint-Like
  • Protein Kinase, Chk2
  • Protein Kinase, LFS2
  • Protein Kinase, PP1425

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2014

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Checkpoint Kinase 2. Medical Subject Headings (MeSH). 2026. Unique ID D064447. http://id.nlm.nih.gov/mesh/2026/D064447
  2. Checkpoint Kinase 2. In: Wikidata. https://www.wikidata.org/wiki/Q5011104