Chemicals and Drugs

Centromere Protein A

A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

6 entry terms
  • CENP-A Protein
  • CENPA Protein
  • Centromere Autoantigens 17K
  • Centromere Protein 17K
  • Autoantigens 17K, Centromere
  • CENP A Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1987)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.687.173
  2. D12.776w.260w.123
  3. D12.776w.660w.235.100
  4. D12.776w.660w.720.173
  5. D12.776w.664w.235.100
  6. D23.050w.422.031

AMA Style

References

  1. National Library of Medicine. Centromere Protein A. Medical Subject Headings (MeSH). 2026. Unique ID D000076247. http://id.nlm.nih.gov/mesh/2026/D000076247
  2. Centromere Protein A. In: Wikidata. https://www.wikidata.org/wiki/Q21109722