Structured Summary
Abstract
Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)
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Classification
Broader headings
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Synonyms
7 entry terms
- Multicellular Spheroids
- Spheroids, Cellular
- Cellular Spheroid
- Multicellular Spheroid
- Spheroid, Cellular
- Spheroid, Multicellular
- Spheroids, Multicellular
MeSH Record
Aspects Covered
15 allowable subheadings
Indexed with the subheadings chemistry, classification, cytology, drug effects, enzymology, immunology, metabolism, microbiology, parasitology, pathology, physiology, radiation effects, transplantation, ultrastructure, virology.
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Indexing Annotation
do not confuse with "spheroid bodies" referring to axons in neuropathol; if tumor spheroids coordinate with TUMOR CELLS, CULTURED
MeSH Record
History Note
2004(1996)
MeSH Record
Previous Indexing
- Cells, Cultured (1972-1995)
- Tissue Culture (1966-1971)
- Tumor Cells, Cultured (1988-1995)
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AMA Style
References
- National Library of Medicine. Cellular Spheroids. Medical Subject Headings (MeSH). 2026. Unique ID D018874. http://id.nlm.nih.gov/mesh/2026/D018874
- Cellular Spheroids. In: Wikidata. https://www.wikidata.org/wiki/Q70062517