Chemicals and Drugs

Cell Adhesion Molecule-1

A cell adhesion molecule that contains extracellular immunoglobulin V and C2 domains. It mediates homophilic and heterophilic cell-cell adhesion independently of calcium, and acts as a tumor suppressor in NON-SMALL-CELL LUNG CANCER (NSCLC) cells. Its interaction with NATURAL KILLER CELLS is important for their cytotoxicity and its expression by MAST CELLS plays a role in their interaction with neurons; it may also function in synapse assembly, nerve growth and differentiation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cell adhesion molecule that contains extracellular immunoglobulin V and C2 domains. It mediates homophilic and heterophilic cell-cell adhesion independently of calcium, and acts as a tumor suppressor in NON-SMALL-CELL LUNG CANCER (NSCLC) cells. Its interaction with NATURAL KILLER CELLS is important for their cytotoxicity and its expression by MAST CELLS plays a role in their interaction with neurons; it may also function in synapse assembly, nerve growth and differentiation.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

7 entry terms
  • CADM1 Protein
  • IGSF4 Protein
  • TSLC1 Protein
  • Tumor Suppressor in Lung Cancer 1 Protein
  • Adhesion Molecule-1, Cell
  • Cell Adhesion Molecule 1
  • Molecule-1, Cell Adhesion

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Cell Adhesion Molecules (2000-2017)
  • Immunoglobulins (2000-2017)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.200w.115
  2. D12.776w.395w.550w.200w.115
  3. D12.776w.543w.550w.200w.128
  4. D23.050w.301.350w.115

AMA Style

References

  1. National Library of Medicine. Cell Adhesion Molecule-1. Medical Subject Headings (MeSH). 2026. Unique ID D000075982. http://id.nlm.nih.gov/mesh/2026/D000075982
  2. Cell Adhesion Molecule-1. In: Wikidata. https://www.wikidata.org/wiki/Q5058171