Phenomena and Processes

Caspase Activation and Recruitment Domain

A homotypic protein interaction module of the death domain superfamily. It is composed of a bundle of six alpha-helices that is related in sequence and structure to the DEATH DOMAIN and DEATH EFFECTOR DOMAIN. The Caspase Activation and Recruitment Domain (CARD domain) typically associates with other CARD-containing proteins, forming either dimers or trimers. CARD domains may occur in isolation, or in combination with other domains in CARD signaling adaptor proteins and initiator CASPASES that function in APOPTOSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A homotypic protein interaction module of the death domain superfamily. It is composed of a bundle of six alpha-helices that is related in sequence and structure to the DEATH DOMAIN and DEATH EFFECTOR DOMAIN. The Caspase Activation and Recruitment Domain (CARD domain) typically associates with other CARD-containing proteins, forming either dimers or trimers. CARD domains may occur in isolation, or in combination with other domains in CARD signaling adaptor proteins and initiator CASPASES that function in APOPTOSIS.

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Classification

Broader headings

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See Also

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Synonyms

7 entry terms
  • CARD Domain
  • CARD Domains
  • Caspase Activation and Recruitment Domains
  • Caspase Recruitment Domain
  • Caspase Recruitment Domains
  • Recruitment Domain, Caspase
  • Recruitment Domains, Caspase

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Amino Acid Sequence (1997-2016)
  • Apoptosis Regulatory Proteins (2006-2016)
  • CARD Signaling Adaptor Proteins (2006-2016)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.750w.500.395.250w

AMA Style

References

  1. National Library of Medicine. Caspase Activation and Recruitment Domain. Medical Subject Headings (MeSH). 2026. Unique ID D000071476. http://id.nlm.nih.gov/mesh/2026/D000071476
  2. Caspase Activation and Recruitment Domain. In: Wikipedia. https://en.wikipedia.org/wiki/CARD_(domain)
  3. Caspase Activation and Recruitment Domain. In: Wikidata. https://www.wikidata.org/wiki/Q24783240