Chemicals and Drugs

Carvedilol

A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION.

Chemical Identity

Chemical Information

Molecular Formula
C24H26N2O4
Molecular Weight
406.5 g/mol
CAS Registry No.
72956-09-3
IUPAC Name
1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
InChIKey
OGHNVEJMJSYVRP-UHFFFAOYSA-N
SMILES
COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
MeSH Unique ID
D000077261
Source
PubChem CID 2585

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

20 entry terms
  • BM 14190
  • BM-14190
  • Carvedilol Hydrochloride
  • Carvedilol, (+)
  • Carvedilol, (+)-isomer
  • Carvedilol, (+-)-isomer
  • Carvedilol, (-)
  • Carvedilol, (-)-isomer
  • Carvedilol, (R)-isomer
  • Carvedilol, (S)-isomer
  • Carvedilol, 14C-labeled
  • Coreg
  • Coropres
  • Dilatrend
  • Eucardic
  • Kredex
  • Querto
  • 14C-labeled Carvedilol
  • BM14190
  • Carvedilol, 14C labeled

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1984)

MeSH Hierarchy

Tree Numbers

  1. D02w.033w.100w.624w.151w
  2. D02w.033w.755.624w.151w
  3. D02w.092w.063w.624w.151w
  4. D03w.633.100.473.144.125w
  5. D03w.633.300.148.125w

AMA Style

References

  1. National Library of Medicine. Carvedilol. Medical Subject Headings (MeSH). 2026. Unique ID D000077261. http://id.nlm.nih.gov/mesh/2026/D000077261
  2. Carvedilol. In: Wikipedia. https://en.wikipedia.org/wiki/Carvedilol
  3. Carvedilol. In: Wikidata. https://www.wikidata.org/wiki/Q412534
  4. Carvedilol. In: PubChem Compound. CID 2585. https://pubchem.ncbi.nlm.nih.gov/compound/2585