Chemicals and Drugs

Carmustine

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)

Chemical Identity

Chemical Information

Molecular Formula
C5H9Cl2N3O2
Molecular Weight
214.05 g/mol
CAS Registry No.
154-93-8
IUPAC Name
1,3-bis(2-chloroethyl)-1-nitrosourea
InChIKey
DLGOEMSEDOSKAD-UHFFFAOYSA-N
SMILES
C(CCl)NC(=O)N(CCCl)N=O
MeSH Unique ID
D002330
Source
PubChem CID 2578

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • 1,3-Bis(2-Chloroethyl)-1-Nitrosourea
  • BCNU
  • FIVB
  • N,N'-Bis(2-Chloroethyl)-N-Nitrosourea
  • BiCNU
  • Nitrumon

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

73(72)

MeSH Record

Previous Indexing

  • Alkylating Agents (1966-1971)
  • Nitroso Compounds (1966-1971)
  • Urea (1966-1971)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.950w.594.247w
  2. D02w.654.692.247w

AMA Style

References

  1. National Library of Medicine. Carmustine. Medical Subject Headings (MeSH). 2026. Unique ID D002330. http://id.nlm.nih.gov/mesh/2026/D002330
  2. Carmustine. In: Wikipedia. https://en.wikipedia.org/wiki/Carmustine
  3. Carmustine. In: Wikidata. https://www.wikidata.org/wiki/Q415869
  4. Carmustine. In: PubChem Compound. CID 2578. https://pubchem.ncbi.nlm.nih.gov/compound/2578