Chemicals and Drugs

Carboxypeptidase B2

A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

10 entry terms
  • Arginine Carboxypeptidase
  • Carboxypeptidase B2, Plasma
  • Carboxypeptidase R
  • Carboxypeptidase U
  • Thrombin-Activatable Fibrinolysis Inhibitor
  • Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)
  • Plasma Carboxypeptidase B2
  • Thrombin Activatable Fibrinolysis Inhibitor
  • Plasma Procarboxypeptidase B
  • Procarboxypeptidase U

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2015 (2002); use CARBOXYPEPTIDASE U (NM) 1994-2001 and LYSINE CARBOXYPEPTIDASE 1997-2001

MeSH Record

Previous Indexing

  • Carboxypeptidases (1979-2001)
  • Lysine Carboxypeptidase (1994-2001)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.350w.245w.125
  2. D08.811w.277w.656w.350w.555w.225
  3. D08.811w.277w.656w.675w.555w.225
  4. D08.811w.277w.656w.837w.092

AMA Style

References

  1. National Library of Medicine. Carboxypeptidase B2. Medical Subject Headings (MeSH). 2026. Unique ID D025901. http://id.nlm.nih.gov/mesh/2026/D025901
  2. Carboxypeptidase B2. In: Wikidata. https://www.wikidata.org/wiki/Q27185317