Chemicals and Drugs

Carbonic Anhydrase IX

A carbonic anhydrase and transmembrane protein that consists of an N-terminal PROTEOGLYCAN-like domain, a catalytic region, a single-pass transmembrane domain, and a short intracellular tail. It functions as a dimer and is expressed primarily by cells of the GASTROINTESTINAL TRACT; BILE DUCT EPITHELIUM; and GALL BLADDER. It is expressed at high levels in many solid tumors, especially CLEAR CELL RENAL CARCINOMA, in response to CELL HYPOXIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A carbonic anhydrase and transmembrane protein that consists of an N-terminal PROTEOGLYCAN-like domain, a catalytic region, a single-pass transmembrane domain, and a short intracellular tail. It functions as a dimer and is expressed primarily by cells of the GASTROINTESTINAL TRACT; BILE DUCT EPITHELIUM; and GALL BLADDER. It is expressed at high levels in many solid tumors, especially CLEAR CELL RENAL CARCINOMA, in response to CELL HYPOXIA.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

2 entry terms
  • CAIX Protein
  • Carbonic Anhydrase 9

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Antigens, Neoplasm (1994-2016)
  • Carbonic Anhydrases (1994-2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.520w.241.300w.150w.450
  2. D12.776w.543w.178
  3. D23.050w.285.196

AMA Style

References

  1. National Library of Medicine. Carbonic Anhydrase IX. Medical Subject Headings (MeSH). 2026. Unique ID D000071231. http://id.nlm.nih.gov/mesh/2026/D000071231
  2. Carbonic Anhydrase IX. In: Wikidata. https://www.wikidata.org/wiki/Q24724080