Chemicals and Drugs

Captopril

A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.

Chemical Identity

Chemical Information

Molecular Formula
C9H15NO3S
Molecular Weight
217.29 g/mol
CAS Registry No.
62571-86-2
IUPAC Name
(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
InChIKey
FAKRSMQSSFJEIM-RQJHMYQMSA-N
SMILES
C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O
MeSH Unique ID
D002216
Source
PubChem CID 44093

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
  • Capoten
  • Lopirin
  • SQ-14,225
  • SQ-14,534
  • SQ-14225
  • SQ-14534
  • SQ 14,225
  • SQ 14,534
  • SQ 14225
  • SQ 14534
  • SQ14,225
  • SQ14,534
  • SQ14225
  • SQ14534

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

86(80); was see under PROLINE 1980-85; SQ 14225 was see CAPTOPRIL 1980-93

MeSH Record

Previous Indexing

  • Kininase II/antagonists & inhibitors (1973-1979)
  • Peptide Peptidohydrolases (1966-1967) /antagonists & inhibitors (1968-1972)
  • Proline (1966-1974) /antagonists & inhibitors (1975-1979)

MeSH Hierarchy

Tree Number

  1. D12.125w.072.401w.623w.270w

AMA Style

References

  1. National Library of Medicine. Captopril. Medical Subject Headings (MeSH). 2026. Unique ID D002216. http://id.nlm.nih.gov/mesh/2026/D002216
  2. Captopril. In: Wikipedia. https://en.wikipedia.org/wiki/Captopril
  3. Captopril. In: Wikidata. https://www.wikidata.org/wiki/Q421119
  4. Captopril. In: PubChem Compound. CID 44093. https://pubchem.ncbi.nlm.nih.gov/compound/44093