Chemicals and Drugs

Canagliflozin

A glucoside-derived SODIUM-GLUCOSE TRANSPORTER 2 inhibitor that stimulates urinary excretion of glucose by suppressing renal glucose reabsorption. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A glucoside-derived SODIUM-GLUCOSE TRANSPORTER 2 inhibitor that stimulates urinary excretion of glucose by suppressing renal glucose reabsorption. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES.

Chemical Identity

Chemical Information

Molecular Formula
C24H25FO5S
Molecular Weight
444.5 g/mol
CAS Registry No.
842133-18-0
IUPAC Name
(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
InChIKey
XTNGUQKDFGDXSJ-ZXGKGEBGSA-N
SMILES
CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F
MeSH Unique ID
D000068896
Source
PubChem CID 24812758

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • 1-(Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene - T777973
  • Canagliflozin Hemihydrate
  • Canagliflozin, Anhydrous
  • Invokana

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (2014)

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.778.075w
  2. D03w.383.903.075w
  3. D09w.408w.348w.113w

AMA Style

References

  1. National Library of Medicine. Canagliflozin. Medical Subject Headings (MeSH). 2026. Unique ID D000068896. http://id.nlm.nih.gov/mesh/2026/D000068896
  2. Canagliflozin. In: Wikipedia. https://en.wikipedia.org/wiki/Canagliflozin
  3. Canagliflozin. In: Wikidata. https://www.wikidata.org/wiki/Q5030940
  4. Canagliflozin. In: PubChem Compound. CID 24812758. https://pubchem.ncbi.nlm.nih.gov/compound/24812758