Structured Summary
Abstract
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Chemical Identity
Chemical Information
- Molecular Formula
- C20H16N2O4
- Molecular Weight
- 348.4 g/mol
- CAS Registry No.
- 7689-03-4
- IUPAC Name
- (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
- InChIKey
- VSJKWCGYPAHWDS-FQEVSTJZSA-N
- SMILES
- CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
- MeSH Unique ID
- D002166
- Source
- PubChem CID 24360
MeSH Record
Classification
Broader headings
Narrower headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
1 entry terms
- Camptothecine
MeSH Record
Aspects Covered
26 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
73
MeSH Record
Previous Indexing
- Alkaloids (1966-1972)
- Antineoplastic Agents (1966-1972)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Camptothecin. Medical Subject Headings (MeSH). 2026. Unique ID D002166. http://id.nlm.nih.gov/mesh/2026/D002166
- Camptothecin. In: Wikipedia. https://en.wikipedia.org/wiki/Camptothecin
- Camptothecin. In: Wikidata. https://www.wikidata.org/wiki/Q419964
- Camptothecin. In: PubChem Compound. CID 24360. https://pubchem.ncbi.nlm.nih.gov/compound/24360