Chemicals and Drugs

Calcineurin

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

8 entry terms
  • Protein Phosphatase 3
  • Protein Phosphatase-2B
  • Phosphatase 3, Protein
  • Protein Phosphatase 2B
  • Calcineurin A
  • Calcineurin B
  • Protein Phosphatase 3 Catalytic Subunit
  • Protein Phosphatase 3 Regulatory Subunit

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

98; see CALCINEURIN (NM) 1987-97

MeSH Record

Previous Indexing

  • Calcium-Binding Proteins (1986-1997)
  • Calmodulin-Binding Proteins (1986-1997)
  • Phosphoprotein Phosphatase (1988-1997)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.650w.625w.150w
  2. D12.644w.360.087w
  3. D12.776w.476.559w.150w

AMA Style

References

  1. National Library of Medicine. Calcineurin. Medical Subject Headings (MeSH). 2026. Unique ID D019703. http://id.nlm.nih.gov/mesh/2026/D019703
  2. Calcineurin. In: Wikipedia. https://en.wikipedia.org/wiki/Calcineurin
  3. Calcineurin. In: Wikidata. https://www.wikidata.org/wiki/Q420566