Chemicals and Drugs

Calcifediol

The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.

Chemical Identity

Chemical Information

Molecular Formula
C27H44O2
Molecular Weight
400.6 g/mol
CAS Registry No.
19356-17-3
IUPAC Name
(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
InChIKey
JWUBBDSIWDLEOM-DTOXIADCSA-N
SMILES
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](CCC3=C)O)C
MeSH Unique ID
D002112
Source
PubChem CID 5283731

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

17 entry terms
  • 25-Hydroxycholecalciferol
  • 25-Hydroxycholecalciferol Monohydrate
  • 25-Hydroxyvitamin D 3
  • 25-Hydroxyvitamin D3
  • Calcidiol
  • 25 Hydroxycholecalciferol
  • 25 Hydroxycholecalciferol Monohydrate
  • 25 Hydroxyvitamin D 3
  • 25 Hydroxyvitamin D3
  • Monohydrate, 25-Hydroxycholecalciferol
  • Calcifediol Anhydrous
  • Calcifediol, (3 alpha,5Z,7E)-Isomer
  • Calcifediol, (3 beta,5E,7E)-Isomer
  • Calderol
  • Dedrogyl
  • Hidroferol
  • Anhydrous, Calcifediol

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

deficiency: coordinate CALCIFEDIOL /defic (IM) with VITAMIN D DEFICIENCY (IM)

MeSH Record

History Note

83

MeSH Record

Previous Indexing

  • Cholecalciferols (1966-1972)
  • Hydroxycholecalciferols (1972-1982)

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.247.222w.159w.478w.250w
  2. D04w.210.500w.247.808w.146w.478w.250w
  3. D04w.210.500w.812w.768w.196w.478w.250w
  4. D10w.570w.938w.146w.478w.250w

AMA Style

References

  1. National Library of Medicine. Calcifediol. Medical Subject Headings (MeSH). 2026. Unique ID D002112. http://id.nlm.nih.gov/mesh/2026/D002112
  2. Calcifediol. In: Wikipedia. https://en.wikipedia.org/wiki/Calcifediol
  3. Calcifediol. In: Wikidata. https://www.wikidata.org/wiki/Q139307
  4. Calcifediol. In: PubChem Compound. CID 5283731. https://pubchem.ncbi.nlm.nih.gov/compound/5283731