Chemicals and Drugs

CLOCK Proteins

Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.

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Synonyms

2 entry terms
  • CLOCK Protein
  • Circadian Locomotor Output Cycles Kaput Proteins

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2010(1997)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.050w.134w.415w.500w.049
  2. D12.644w.360.138.100
  3. D12.776w.260w.103w.562
  4. D12.776w.476.156.200
  5. D12.776w.930w.125w.562

AMA Style

References

  1. National Library of Medicine. CLOCK Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D056926. http://id.nlm.nih.gov/mesh/2026/D056926
  2. CLOCK Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q3610562