Structured Summary
Abstract
Protein modules that function in the targeting of proteins to CELL MEMBRANES. They consist of an eight-stranded anti-parallel beta-sandwich composed of a pair of four-stranded beta-sheets. This structural unit forms a pocket on the membrane-interacting face of the protein and co-ordinates the binding of 2 to 3 calcium ions; however, not all C2 domains bind calcium. Examples of C2 domain-containing proteins include PROTEIN KINASE C and PTEN PHOSPHOHYDROLASE.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Loading graph…
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
10 entry terms
- C2 Domain
- Domain, C2
- Domains, C2
- C2 Tensin-type Domain
- C2 Tensin type Domain
- C2 Tensin-type Domains
- Domain, C2 Tensin-type
- Domains, C2 Tensin-type
- Tensin-type Domain, C2
- Tensin-type Domains, C2
MeSH Record
Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Amino Acid Sequence (1990-2016)
- Protein Binding (1990-2016)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. C2 Domains. Medical Subject Headings (MeSH). 2026. Unique ID D000070538. http://id.nlm.nih.gov/mesh/2026/D000070538
- C2 Domains. In: Wikipedia. https://en.wikipedia.org/wiki/C2_domain
- C2 Domains. In: Wikidata. https://www.wikidata.org/wiki/Q5008102