Structured Summary
Abstract
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
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Broader headings
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Drug Class
Pharmacological Action
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Synonyms
1 entry terms
- Sulfoximine, Buthionine
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Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
97: was BUTHIONINE SULFOXIMINE (NM) 1979-96
MeSH Record
Previous Indexing
- Methionine Sulfoximine (1979-1996)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Buthionine Sulfoximine. Medical Subject Headings (MeSH). 2026. Unique ID D019328. http://id.nlm.nih.gov/mesh/2026/D019328
- Buthionine Sulfoximine. In: Wikipedia. https://en.wikipedia.org/wiki/Buthionine_sulfoximine
- Buthionine Sulfoximine. In: Wikidata. https://www.wikidata.org/wiki/Q5002519