Chemicals and Drugs

Busulfan

An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.

Chemical Identity

Chemical Information

Molecular Formula
C6H14O6S2
Molecular Weight
246.3 g/mol
CAS Registry No.
55-98-1
IUPAC Name
4-methylsulfonyloxybutyl methanesulfonate
InChIKey
COVZYZSDYWQREU-UHFFFAOYSA-N
SMILES
CS(=O)(=O)OCCCCOS(=O)(=O)C
MeSH Unique ID
D002066
Source
PubChem CID 2478

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • Busulphan
  • Busulfan Wellcome
  • Busulfex
  • Glyzophrol
  • Myelosan
  • Mylecytan
  • Myleran
  • Myléran
  • n-Butane-1,3-di(methylsulfonate)
  • Wellcome, Busulfan

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Numbers

  1. D02w.033w.455.125w.125w
  2. D02w.455w.326.146w.100.050.500w.100w
  3. D02w.886w.645.600w.055.050.510w.100w

AMA Style

References

  1. National Library of Medicine. Busulfan. Medical Subject Headings (MeSH). 2026. Unique ID D002066. http://id.nlm.nih.gov/mesh/2026/D002066
  2. Busulfan. In: Wikipedia. https://en.wikipedia.org/wiki/Busulfan
  3. Busulfan. In: Wikidata. https://www.wikidata.org/wiki/Q348922
  4. Busulfan. In: PubChem Compound. CID 2478. https://pubchem.ncbi.nlm.nih.gov/compound/2478