Chemicals and Drugs

Buspirone

An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.

Chemical Identity

Chemical Information

Molecular Formula
C21H31N5O2
Molecular Weight
385.5 g/mol
CAS Registry No.
36505-84-7
IUPAC Name
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
InChIKey
QWCRAEMEVRGPNT-UHFFFAOYSA-N
SMILES
C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
MeSH Unique ID
D002065
Source
PubChem CID 2477

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

25 entry terms
  • N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide
  • Anxut
  • Apo-Buspirone
  • Bespar
  • Busp
  • Buspar
  • Buspirone Hydrochloride
  • Gen-Buspirone
  • Lin-Buspirone
  • MJ-9022-1
  • Neurosine
  • Novo-Buspirone
  • Nu-Buspirone
  • PMS-Buspirone
  • Ratio-Buspirone
  • Apo Buspirone
  • Gen Buspirone
  • Hydrochloride, Buspirone
  • Lin Buspirone
  • MJ 9022 1
  • MJ90221
  • Novo Buspirone
  • Nu Buspirone
  • PMS Buspirone
  • Ratio Buspirone

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

88

MeSH Record

Previous Indexing

  • Pyrimidines (1972-1987)
  • Spiro Compounds (1973-1982)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.779w.120w
  2. D03w.383.606w.210w
  3. D03w.383.742.120w
  4. D04w.711w.120w

MeSH Record

NLM Classification

QV 77.9

AMA Style

References

  1. National Library of Medicine. Buspirone. Medical Subject Headings (MeSH). 2026. Unique ID D002065. http://id.nlm.nih.gov/mesh/2026/D002065
  2. Buspirone. In: Wikipedia. https://en.wikipedia.org/wiki/Buspirone
  3. Buspirone. In: Wikidata. https://www.wikidata.org/wiki/Q412194
  4. Buspirone. In: PubChem Compound. CID 2477. https://pubchem.ncbi.nlm.nih.gov/compound/2477