Chemicals and Drugs

Bromodeoxyuridine

A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.

Chemical Identity

Chemical Information

Molecular Formula
C9H11BrN2O5
Molecular Weight
307.10 g/mol
CAS Registry No.
59-14-3
IUPAC Name
5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
InChIKey
WOVKYSAHUYNSMH-RRKCRQDMSA-N
SMILES
C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Br)CO)O
MeSH Unique ID
D001973
Source
PubChem CID 6035

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • 5-Bromo-2'-deoxyuridine
  • 5-Bromodeoxyuridine
  • BUdR
  • BrdU
  • Bromouracil Deoxyriboside
  • Broxuridine
  • 5 Bromo 2' deoxyuridine
  • 5 Bromodeoxyuridine
  • Deoxyriboside, Bromouracil
  • NSC-38297

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

66(65)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.742.680.852w.300w.150w
  2. D13.570w.230w.430w.196w
  3. D13.570w.685.852w.300w.150w

AMA Style

References

  1. National Library of Medicine. Bromodeoxyuridine. Medical Subject Headings (MeSH). 2026. Unique ID D001973. http://id.nlm.nih.gov/mesh/2026/D001973
  2. Bromodeoxyuridine. In: Wikipedia. https://en.wikipedia.org/wiki/Bromodeoxyuridine
  3. Bromodeoxyuridine. In: Wikidata. https://www.wikidata.org/wiki/Q419861
  4. Bromodeoxyuridine. In: PubChem Compound. CID 6035. https://pubchem.ncbi.nlm.nih.gov/compound/6035