Phenomena and Processes

Brain-Gut Axis

An interactive network between the GASTROINTESTINAL TRACT (gut) and the brain principally mediated through the ENTERIC NERVOUS SYSTEM. Control of the gut activities during stress, for instance, is mediated by activation of neuroendocrine hormones (e.g., CORTICOTROPIN-RELEASING FACTOR). Conversely, INTESTINAL MICROBIOTA associate with the CENTRAL NERVOUS SYSTEM through the axis via microorganism-derived products (e.g., UROCORTINS). Some functional GASTROINTESTINAL DISORDERS (e.g., IRRITABLE BOWEL SYNDROME) have dysregulated brain-gut axis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An interactive network between the GASTROINTESTINAL TRACT (gut) and the brain principally mediated through the ENTERIC NERVOUS SYSTEM. Control of the gut activities during stress, for instance, is mediated by activation of neuroendocrine hormones (e.g., CORTICOTROPIN-RELEASING FACTOR). Conversely, INTESTINAL MICROBIOTA associate with the CENTRAL NERVOUS SYSTEM through the axis via microorganism-derived products (e.g., UROCORTINS). Some functional GASTROINTESTINAL DISORDERS (e.g., IRRITABLE BOWEL SYNDROME) have dysregulated brain-gut axis.

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Broader headings

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See Also

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Synonyms

25 entry terms
  • Brain and Gut Axis
  • Gut and Brain Axis
  • Gut-Brain Axis
  • Axis, Brain-Gut
  • Axis, Gut-Brain
  • Brain Gut Axis
  • Gut Brain Axis
  • Brain-Gut-Microbiome Axis
  • Gut-Brain-Microbiome Axis
  • Microbiome-Brain-Gut Axis
  • Microbiome-Gut-Brain Axis
  • Microbiota-Brain-Gut Axis
  • Microbiota-Gut-Brain Axis
  • Axis, Brain-Gut-Microbiome
  • Axis, Gut-Brain-Microbiome
  • Axis, Microbiome-Brain-Gut
  • Axis, Microbiome-Gut-Brain
  • Axis, Microbiota-Brain-Gut
  • Axis, Microbiota-Gut-Brain
  • Brain Gut Microbiome Axis
  • Gut Brain Microbiome Axis
  • Microbiome Brain Gut Axis
  • Microbiome Gut Brain Axis
  • Microbiota Brain Gut Axis
  • Microbiota Gut Brain Axis

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2022

MeSH Record

Previous Indexing

  • Brain (1980-2021)
  • Digestive System Physiological Phenomena (1981-2021)
  • Gastrointestinal Microbiome (2015-2021)
  • Gastrointestinal Tract (2003-2021)

MeSH Hierarchy

Tree Number

  1. G11.561.138w

AMA Style

References

  1. National Library of Medicine. Brain-Gut Axis. Medical Subject Headings (MeSH). 2026. Unique ID D000087502. http://id.nlm.nih.gov/mesh/2026/D000087502
  2. Brain-Gut Axis. In: Wikipedia. https://en.wikipedia.org/wiki/Gut%E2%80%93brain_axis
  3. Brain-Gut Axis. In: Wikidata. https://www.wikidata.org/wiki/Q17077315