Structured Summary
Abstract
A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage PULMONARY HYPERTENSION and SYSTEMIC SCLEROSIS.
Chemical Identity
Chemical Information
- Molecular Formula
- C27H29N5O6S
- Molecular Weight
- 551.6 g/mol
- CAS Registry No.
- 147536-97-8
- IUPAC Name
- 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
- InChIKey
- GJPICJJJRGTNOD-UHFFFAOYSA-N
- SMILES
- CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC
- MeSH Unique ID
- D000077300
- Source
- PubChem CID 104865
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- 4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
- Bosentan Anhydrous
- Bosentan Monohydrate
- Ro 47-0203
- Ro-47-0203
- Tracleer
- Ro 47 0203
- Ro 470203
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1994)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Bosentan. Medical Subject Headings (MeSH). 2026. Unique ID D000077300. http://id.nlm.nih.gov/mesh/2026/D000077300
- Bosentan. In: Wikipedia. https://en.wikipedia.org/wiki/Bosentan
- Bosentan. In: Wikidata. https://www.wikidata.org/wiki/Q419769
- Bosentan. In: PubChem Compound. CID 104865. https://pubchem.ncbi.nlm.nih.gov/compound/104865