Structured Summary
Abstract
A pyrazine and boronic acid derivative that functions as a reversible PROTEASOME INHIBITOR. It is used as an ANTINEOPLASTIC AGENT in the treatment of MULTIPLE MYELOMA and MANTLE CELL LYMPHOMA.
Chemical Identity
Chemical Information
- Molecular Formula
- C19H25BN4O4
- Molecular Weight
- 384.2 g/mol
- CAS Registry No.
- 179324-69-7
- IUPAC Name
- [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
- InChIKey
- GXJABQQUPOEUTA-RDJZCZTQSA-N
- SMILES
- B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
- MeSH Unique ID
- D000069286
- Source
- PubChem CID 387447
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- LDP-341
- PS 341
- PS-341
- Velcade
- 341, PS
- LDP 341
- LDP341
- PS341
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2016 (2000)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Bortezomib. Medical Subject Headings (MeSH). 2026. Unique ID D000069286. http://id.nlm.nih.gov/mesh/2026/D000069286
- Bortezomib. In: Wikipedia. https://en.wikipedia.org/wiki/Bortezomib
- Bortezomib. In: Wikidata. https://www.wikidata.org/wiki/Q419319
- Bortezomib. In: PubChem Compound. CID 387447. https://pubchem.ncbi.nlm.nih.gov/compound/387447