Chemicals and Drugs

Bisbenzimidazole

A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.

Chemical Identity

Chemical Information

Molecular Formula
C25H24N6O
Molecular Weight
424.5 g/mol
CAS Registry No.
23491-44-3
IUPAC Name
4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenol
InChIKey
INAAIJLSXJJHOZ-UHFFFAOYSA-N
SMILES
CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC=C(C=C6)O
MeSH Unique ID
D006690
Source
PubChem CID 2392

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • Pibenzimol
  • 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol, trihydrochloride
  • Bisbenzimidazole Trihydrochloride
  • Bisbenzimide
  • Hoe-33258
  • Hoechst 33258
  • NSC-322921
  • Hoe 33258
  • Hoe33258
  • NSC 322921
  • NSC322921

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2008(1977)

MeSH Record

Previous Indexing

  • Benzimidazoles (1971-1976)
  • Phenols (1972-1975)
  • Piperazines (1971-1975)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.103.145

AMA Style

References

  1. National Library of Medicine. Bisbenzimidazole. Medical Subject Headings (MeSH). 2026. Unique ID D006690. http://id.nlm.nih.gov/mesh/2026/D006690
  2. Bisbenzimidazole. In: Wikidata. https://www.wikidata.org/wiki/Q27123162
  3. Bisbenzimidazole. In: PubChem Compound. CID 2392. https://pubchem.ncbi.nlm.nih.gov/compound/2392