Structured Summary
Abstract
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
Chemical Identity
Chemical Information
- Molecular Formula
- C20H17NO6
- Molecular Weight
- 367.4 g/mol
- CAS Registry No.
- 485-49-4
- IUPAC Name
- (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
- InChIKey
- IYGYMKDQCDOMRE-ZWKOTPCHSA-N
- SMILES
- CN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
- MeSH Unique ID
- D001640
- Source
- PubChem CID 10237
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
1 entry terms
- 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
80(75); was see under ISOQUINOLINES 1975-79
MeSH Record
Previous Indexing
- Alkaloids (1972-1974)
- Dioxoles (1972-1974)
- Isoquinolines (1971-1974)
MeSH Hierarchy
Tree Numbers
MeSH Record
NLM Classification
QV 103
AMA Style
References
- National Library of Medicine. Bicuculline. Medical Subject Headings (MeSH). 2026. Unique ID D001640. http://id.nlm.nih.gov/mesh/2026/D001640
- Bicuculline. In: Wikipedia. https://en.wikipedia.org/wiki/Bicuculline
- Bicuculline. In: Wikidata. https://www.wikidata.org/wiki/Q3639734
- Bicuculline. In: PubChem Compound. CID 10237. https://pubchem.ncbi.nlm.nih.gov/compound/10237