Chemicals and Drugs

Benserazide

An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone.

Chemical Identity

Chemical Information

Molecular Formula
C10H15N3O5
Molecular Weight
257.24 g/mol
CAS Registry No.
322-35-0
IUPAC Name
2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide
InChIKey
BNQDCRGUHNALGH-UHFFFAOYSA-N
SMILES
C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O
MeSH Unique ID
D001545
Source
PubChem CID 2327

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • DL-Serine 2-((2,3,4-trihydroxyphenyl)methyl)hydrazide
  • Serazide
  • Seryltrihydroxy Benzylhydrazine
  • Seryltrihydroxybenzylhydrazine
  • Benzylhydrazine, Seryltrihydroxy
  • Ro 4-4602
  • Ro 4 4602
  • Ro 44602

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(79); was see under HYDRAZINES 1979-90; was SERYLTRIHYDROXY BENZYLHYDRAZINE see under HYDRAZINES 1973-78 (Prov 1973-74)

MeSH Record

Previous Indexing

  • Benzene (1966-1967)
  • Benzene Derivatives (1968-1971)
  • Benzyl Compounds (1972)
  • Hydrazines (1966-1972)
  • Serine (1966-1972)

MeSH Hierarchy

Tree Number

  1. D02w.442w.175w

AMA Style

References

  1. National Library of Medicine. Benserazide. Medical Subject Headings (MeSH). 2026. Unique ID D001545. http://id.nlm.nih.gov/mesh/2026/D001545
  2. Benserazide. In: Wikipedia. https://en.wikipedia.org/wiki/Benserazide
  3. Benserazide. In: Wikidata. https://www.wikidata.org/wiki/Q818165
  4. Benserazide. In: PubChem Compound. CID 2327. https://pubchem.ncbi.nlm.nih.gov/compound/2327