Structured Summary
Abstract
A homodimerization protein interaction domain occurring at the N terminus of proteins that contain multiple copies of either CYS2-HIS2 ZINC FINGERS or KELCH REPEATS. It is characterized by a tightly intertwined dimer with an extensive hydrophobic interface. A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggesting a peptide-binding site. Many BTB proteins are transcriptional regulators that are thought to regulate CHROMATIN structure.
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Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
10 entry terms
- BTB (POZ) Domain
- BTB Domain
- Broad-Complex, Tramtrack and Bric a Brac Domain
- POZ Domain
- POxvirus and Zinc Finger Domain
- BTB Domains
- BTB POZ Domain
- BTB-POZ Domains
- Broad Complex, Tramtrack and Bric a Brac Domain
- POZ Domains
MeSH Record
Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Amino Acid Sequence (1994-2016)
- DNA-Binding Proteins (1994-2016)
- Protein Structure, Tertiary (1995-2016)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. BTB-POZ Domain. Medical Subject Headings (MeSH). 2026. Unique ID D000071757. http://id.nlm.nih.gov/mesh/2026/D000071757
- BTB-POZ Domain. In: Wikipedia. https://en.wikipedia.org/wiki/BTB/POZ_domain
- BTB-POZ Domain. In: Wikidata. https://www.wikidata.org/wiki/Q24771346