Phenomena and Processes

BRCA2 Genes

A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)

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Classification

Broader headings

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See Also

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Synonyms

3 entry terms
  • BRCA2 Gene
  • Genes, BRCA2
  • Gene, BRCA2

MeSH Record

Aspects Covered

4 allowable subheadings

Indexed with the subheadings drug effects, ethics, physiology, radiation effects.

MeSH Record

Indexing Annotation

BRCA stands for "BReast CAncer"

MeSH Record

History Note

2002

MeSH Record

Previous Indexing

  • Genes, Tumor Suppressor (1995-2001)

MeSH Hierarchy

Tree Numbers

  1. G05.360w.340w.024.340w.375.249w.105
  2. G05.360w.340w.024.340w.415.400w.105

AMA Style

References

  1. National Library of Medicine. BRCA2 Genes. Medical Subject Headings (MeSH). 2026. Unique ID D024522. http://id.nlm.nih.gov/mesh/2026/D024522
  2. BRCA2 Genes. In: Wikidata. https://www.wikidata.org/wiki/Q17853272