Structured Summary
Abstract
A benzamide and indazole derivative that acts as a TYROSINE KINASE inhibitor of the VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR. It is used in the treatment of advanced RENAL CELL CARCINOMA.
Chemical Identity
Chemical Information
- Molecular Formula
- C22H18N4OS
- Molecular Weight
- 386.5 g/mol
- CAS Registry No.
- 319460-85-0
- IUPAC Name
- N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
- InChIKey
- RITAVMQDGBJQJZ-FMIVXFBMSA-N
- SMILES
- CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4
- MeSH Unique ID
- D000077784
- Source
- PubChem CID 6450551
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
4 entry terms
- AG 013736
- AG-013736
- AG013736
- Inlyta
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (2005)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Axitinib. Medical Subject Headings (MeSH). 2026. Unique ID D000077784. http://id.nlm.nih.gov/mesh/2026/D000077784
- Axitinib. In: Wikipedia. https://en.wikipedia.org/wiki/Axitinib
- Axitinib. In: Wikidata. https://www.wikidata.org/wiki/Q4830631
- Axitinib. In: PubChem Compound. CID 6450551. https://pubchem.ncbi.nlm.nih.gov/compound/6450551