Structured Summary
Abstract
An autophagy-related protein that functions in AUTOPHAGOSOME biogenesis. It is conjugated to the ATG12 PROTEIN via a process that is similar to UBIQUITINATION and involves the ATG7 PROTEIN and ATG10 enzyme. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme and is required for the localization of ATG8 PROTEINS to AUTOPHAGOSOME vesicle membranes and modification of membrane lipids.
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Classification
Broader headings
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Synonyms
10 entry terms
- ATG-5 Protein
- ATG5 Protein
- Apoptosis-Specific Protein
- Autophagy Protein-5
- Autophagy-Related 5 Protein
- ATG 5 Protein
- Apoptosis Specific Protein
- Autophagy Protein 5
- Autophagy Related 5 Protein
- Autophagy Related Protein 5
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Microtubule-Associated Proteins (2004-2016)
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AMA Style
References
- National Library of Medicine. Autophagy-Related Protein 5. Medical Subject Headings (MeSH). 2026. Unique ID D000071187. http://id.nlm.nih.gov/mesh/2026/D000071187
- Autophagy-Related Protein 5. In: Wikidata. https://www.wikidata.org/wiki/Q24775096