Structured Summary
Abstract
A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
8 entry terms
- Serine-Threonine Protein Kinase ULK1
- ULK1 Protein
- Unc-51 Like Autophagy Activating Kinase 1
- Unc-51-Like Kinase 1
- Autophagy Related Protein 1 Homolog
- Serine Threonine Protein Kinase ULK1
- Unc 51 Like Autophagy Activating Kinase 1
- Unc 51 Like Kinase 1
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Protein-Serine-Threonine Kinases (1998-2016)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Autophagy-Related Protein-1 Homolog. Medical Subject Headings (MeSH). 2026. Unique ID D000071189. http://id.nlm.nih.gov/mesh/2026/D000071189
- Autophagy-Related Protein-1 Homolog. In: Wikidata. https://www.wikidata.org/wiki/Q78039936