Chemicals and Drugs

Arylsulfotransferase

A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3',5'-bisphosphate. A number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. Sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. EC 2.8.2.1.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3',5'-bisphosphate. A number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. Sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. EC 2.8.2.1.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

22 entry terms
  • Aryl Sulfotransferase
  • Phenol Sulfokinase
  • Phenol Sulfotransferase
  • Phenolsulfokinase
  • Sulfokinase
  • Sulfotransferase, Aryl
  • Sulfotransferase, Phenol
  • Acetaminophen Sulphotransferase
  • Catecholamine Sulfotransferase A
  • Catecholamine Sulfotransferase B
  • Dopamine Sulfotransferase
  • Flavonoid Sulfotransferase
  • Phenol Sulfotransferase M
  • Phenol Sulfotransferase P
  • Phenolsulfotransferase P
  • Sulfotransferase A, Catecholamine
  • Sulfotransferase B, Catecholamine
  • Sulfotransferase M, Phenol
  • Sulfotransferase P, Phenol
  • Sulfotransferase, Dopamine
  • Sulfotransferase, Flavonoid
  • Sulphotransferase, Acetaminophen

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • Sulfurtransferases (1972-1988)
  • Transferases (1966-1971)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.817.400w.300w

AMA Style

References

  1. National Library of Medicine. Arylsulfotransferase. Medical Subject Headings (MeSH). 2026. Unique ID D015239. http://id.nlm.nih.gov/mesh/2026/D015239
  2. Arylsulfotransferase. In: Wikipedia. https://en.wikipedia.org/wiki/Aryl-sulfate_sulfotransferase
  3. Arylsulfotransferase. In: Wikidata. https://www.wikidata.org/wiki/Q4802696