Chemicals and Drugs

Aprotinin

A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

21 entry terms
  • BPTI, Basic Pancreatic Trypsin Inhibitor
  • Basic Pancreatic Trypsin Inhibitor
  • Bovine Kunitz Pancreatic Trypsin Inhibitor
  • Bovine Pancreatic Trypsin Inhibitor
  • Kallikrein-Trypsin Inactivator
  • Kunitz Pancreatic Trypsin Inhibitor
  • Trypsin Inhibitor, Basic, Pancreatic
  • Trypsin Inhibitor, Kunitz, Pancreatic
  • Inactivator, Kallikrein-Trypsin
  • Kallikrein Trypsin Inactivator
  • Antilysin
  • Contrical
  • Contrykal
  • Dilmintal
  • Iniprol
  • Kontrikal
  • Kontrykal
  • Pulmin
  • Traskolan
  • Trasylol
  • Zymofren

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

90; was KALLIKREIN-TRYPSIN INACTIVATOR 1966-89

MeSH Hierarchy

Tree Number

  1. D12.776w.083w

MeSH Record

NLM Classification

QU 143

AMA Style

References

  1. National Library of Medicine. Aprotinin. Medical Subject Headings (MeSH). 2026. Unique ID D007611. http://id.nlm.nih.gov/mesh/2026/D007611
  2. Aprotinin. In: Wikipedia. https://en.wikipedia.org/wiki/Aprotinin
  3. Aprotinin. In: Wikidata. https://www.wikidata.org/wiki/Q418625