Chemicals and Drugs

Aprepitant

A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING.

Chemical Identity

Chemical Information

Molecular Formula
C23H21F7N4O3
Molecular Weight
534.4 g/mol
CAS Registry No.
170729-80-3
IUPAC Name
3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4-dihydro-1,2,4-triazol-5-one
InChIKey
ATALOFNDEOCMKK-OITMNORJSA-N
SMILES
C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F
MeSH Unique ID
D000077608
Source
PubChem CID 135413536

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

18 entry terms
  • (1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine
  • (2R)-(1R)-3,5-bis(Trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine
  • Emend
  • L 754,030
  • L 754030
  • L-754,030
  • L-754030
  • MK 0517
  • MK 0869
  • MK 869
  • MK-0517
  • MK-0869
  • MK-869
  • MK0517
  • L754,030
  • L754030
  • MK0869
  • MK869

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1998)

MeSH Hierarchy

Tree Number

  1. D03w.383.533.640.125w

AMA Style

References

  1. National Library of Medicine. Aprepitant. Medical Subject Headings (MeSH). 2026. Unique ID D000077608. http://id.nlm.nih.gov/mesh/2026/D000077608
  2. Aprepitant. In: Wikipedia. https://en.wikipedia.org/wiki/Aprepitant
  3. Aprepitant. In: Wikidata. https://www.wikidata.org/wiki/Q621834
  4. Aprepitant. In: PubChem Compound. CID 135413536. https://pubchem.ncbi.nlm.nih.gov/compound/135413536