Structured Summary
Abstract
Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
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Synonyms
4 entry terms
- Apoptosomal Protein Complex
- Apoptosome
- Complex, Apoptosomal Protein
- Protein Complex, Apoptosomal
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2007
MeSH Record
Previous Indexing
- Apoptosis (1999-2006)
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AMA Style
References
- National Library of Medicine. Apoptosomes. Medical Subject Headings (MeSH). 2026. Unique ID D053478. http://id.nlm.nih.gov/mesh/2026/D053478
- Apoptosomes. In: Wikipedia. https://en.wikipedia.org/wiki/Apoptosome
- Apoptosomes. In: Wikidata. https://www.wikidata.org/wiki/Q2061363