Chemicals and Drugs

Apolipoproteins B

Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.

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Synonyms

5 entry terms
  • Apo B
  • Apo-B
  • ApoB
  • Apoprotein (B)
  • Apoproteins B

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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History Note

85; APOLIPOPROTEIN B was see APOLIPOPROTEINS B 1985-93

MeSH Record

Previous Indexing

  • Apolipoproteins (1977-1984)

MeSH Hierarchy

Tree Numbers

  1. D10w.532w.091w.300
  2. D12.776w.070.400w.300
  3. D12.776w.521w.120w.300

AMA Style

References

  1. National Library of Medicine. Apolipoproteins B. Medical Subject Headings (MeSH). 2026. Unique ID D001055. http://id.nlm.nih.gov/mesh/2026/D001055
  2. Apolipoproteins B. In: Wikidata. https://www.wikidata.org/wiki/Q648343