Chemicals and Drugs

Apolipoprotein L1

An ApoL protein highly expressed by the liver. It has anti-trypanosomal activity through its ability to permeabilize TRYPANOSOMA membranes. Mutations in the APOL1 gene are associated with type 4 FOCAL SEGMENTAL GLOMERULOSCLEROSIS .

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An ApoL protein highly expressed by the liver. It has anti-trypanosomal activity through its ability to permeabilize TRYPANOSOMA membranes. Mutations in the APOL1 gene are associated with type 4 FOCAL SEGMENTAL GLOMERULOSCLEROSIS .

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

3 entry terms
  • ApoL Protein
  • ApoL1 Protein
  • Apolipoprotein L

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Apolipoproteins (1997-2017)
  • Lipoproteins, HDL (1997-2017)

MeSH Hierarchy

Tree Numbers

  1. D10w.532w.091w.750w.500
  2. D12.776w.070.400w.750w.500
  3. D12.776w.521w.120w.750w.500

AMA Style

References

  1. National Library of Medicine. Apolipoprotein L1. Medical Subject Headings (MeSH). 2026. Unique ID D000075944. http://id.nlm.nih.gov/mesh/2026/D000075944
  2. Apolipoprotein L1. In: Wikidata. https://www.wikidata.org/wiki/Q21112667